Pre-eclamptic toxaemia in the current pregnancy in relation to NVP or HG



1.   No correlation between nausea and pre-eclamptic toxaemia. 853 singleton deliveries. (6)

2.   There is no difference in emesis gravidarum between patients with oedema and those without it. Oedema was reported in 30 patients. In late pregnancy, 5 patients developed proteinuria, 4 of them had suffered from emesis gravidarum in early pregnancy. 102 women in study. (19)

3.   There was no association between hours of nausea and pre-eclamptic toxaemia in current pregnancy. P=0.89. 363 women. (53)

4.   The incidence of pre-eclampsia was not different between vomiting and non-vomiting patients. 3.0% PET with no NVP 361 women. 3.9% PET with vomiting. 922 women. (63)

5.   Vomiting was not more common in women with proteinuria 2+ or greater. 4,517 women vomited, 3,502 women did not vomit. (18)

6.   It would not appear that patients suffering from hyperemesis have any greater risk of developing toxaemia in late pregnancy than does the general obstetric population. (10)

7.   There was no significant difference in the incidence of eclampsia in the current pregnancy between women with hyperemesis and controls. 164 women with hyperemesis gravidarum, 209 controls. (64)

8.   Even after controlling for chronic hypertension a modest association between severe vomiting and pre-eclampsia was still present. 1,867 subjects with single births. 1,666 had no vomiting, 201 with severe vomiting. Definition of severe vomiting not included. (65)

9.   24 women with eclampsia in 1,379 deliveries, 6 (25%) had hyperemesis gravidarum.
Definition of HG not included. (68)

10.   Maternal diagnosis of pre-eclampsia was less frequent when the woman had used meclozine. 16,536 women used meclozine in the first 12 weeks of pregnancy. Meclozine was mainly used for NVP. (133)



Women with pre-eclamptic toxaemia no increase in NVP. 23,457 women in 8 studies with NVP

(6) (10) (18) (19) (53) t (63) (64) (133)                                    Total:            Eight References


Modest association between severe vomiting and pre-eclampsia. (65)

                                                                                                Total:            One Reference


High incidence of hyperemesis gravidarum in eclamptic patients. (68)

                                                                                                Total:            One Reference


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Evidence is mounting from biological research that GDF15, the key driver of cancer cachexia, is linked to severe NVP

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