NVP or HG in relation to birth weight of baby
32. NVP OR HG IN RELATION TO BIRTH WEIGHT OF BABY
1. Infants of vomiting mothers were not more likely to be of low birth weight than were infants of non-vomiting mothers in either the crude or adjusted analysis. Birth weight < 2,500g p=0.45, the mean birth weight of infants born to mothers both with and without vomiting was 3,203g. 4,517 women reported vomiting and 3,502 women did not vomit by 16 weeks. (18)t
2. There were no differences in birth weights between the two groups, those with NVP or those with no symptoms. 62 women complained of emesis gravidarum. 28 had no symptoms of NVP. (19)
3. NVP not related to birth weight. 873 women in study, 602 women (69%) had NVP. (44)
4. No significant relationship was found between infant birth weight and any of the subscales, i.e. nausea, vomiting or retching. Pregnancy resulted in a live birth for 100 women. (48)
5. NVP not related to birth weight. 363 women with normal live singleton deliveries. 292 women had NVP. (53)
6. Our observations indicate that nausea and vomiting of pregnancy does not imply an excess risk of low birth weight. 309 singleton pregnancies. (13)
7. Birth weight, 3,286 ± 659g. 162 patients treated for HG over three years. (82)
8. Birth weights of babies the same for all four groups of NVP. 1,453 women with singleton pregnancy - Gr1 No symptoms; Gr2 Nausea only; Gr3 Vomiting; Gr4 HG. (63)
9. The occurrence of nausea and vomiting did not predict the birth weight of the child. 160 women in study. (80)
10. No ifference in birth weight for babies with morning sickness, 3,289 ± 553gms (67%) and mothers with no morning sickness, 3,179 ± 466gms (33%).
180 women in study. (104)
11. There is certainly no suggestion that the patient who suffers from hyperemesis gravidarum is likely to produce an underweight baby. 105 hyperemesis gravidarum cases. (10)
12. Average birth weight of 30 babies delivered to women with hyperemesis gravidarum. Average weight: 3.585 kgm = 7.8 lbs. (36)
13. Pregnancy outcome between hyperemesis gravidarum patients and the general population was similar for birth weight. 193 hyperemesis gravidarum patients, 13,053 women in study population. (61)
14. The mean birth weights were 3.100, 3.093, 3.160 kgms in the mild hyperemesis gravidarum, severe hyperemesis gravidarum and control groups respectively. 40 patients were diagnosed as having mild hyperemesis gravidarum and 98 as having severe hyperemesis gravidarum. 12,335 patients were defined as controls. (62)
15. There was no statistical difference in the average birth weight of the baby between women with hyperemesis gravidarum (164) and the control group (209). 3.1229 kgms hyperemesis gravidarum, 3.1429 kgms control. (64)
16. The birth weights of infants (n=9) with hyperemesis gravidarum attained, and slightly surpassed, the mean birth weight for gestational age. (73)
17. The mean birth weight of the babies in the severe hyperemetic group was significantly lower than in both the mild hyperemesis gravidarum group (P0.43). (28)
18. In hyperemesis gravidarum increased incidence of low birth weight. 3,068 women with hyperemesis gravidarum in nearly one million births. (29)
19. Women with hyperemesis gravidarum causing a loss of greater than 5% of their pre- pregnancy weight, Group A n=30, were compared to women with symptoms of nausea and vomiting, but maintaining at least 95% of their pregnancy weight Group B, n=34. Group A babies significantly smaller with respect to birth weight expressed as a percentage for gestational age. (42)
20. Hyperemesis gravidarum. A comparison of single and multiple admissions. Women admitted repeatedly have babies with reduced neonatal birth weights. 2,806g ± 676g compared to 3,071g ± 477g. Study population 140 patients, 70 were admitted on only one occasion. 39 women (28%) were admitted on multiple occasions. 31 patients were lost to follow up or elected to undergo a therapeutic abortion. (33)
21. 7.9% of gravidas who did not experience NVP were delivered of low birth weight babies, whereas only 5.6% of the N & V group had low birth weight, significant. 1,910 women experienced no N & V. 5,111 experienced N & V. (5)
22. Low birth weight associated with absence of NVP. 199 women who bore single live children, 72% experienced NVP. (11)
23. A larger proportion of low birth weight infants were delivered of women having no symptoms of NVP. 414 women, 44 women had no NVP (10.6%). (21)
24. Pregnancy outcome of 17 patients with hyperemesis gravidarum. Mean birth weight was 3,176 ± 539 gm. All babies weighed >2500gm. (125)
25. Compared to women without hyperemesis (n=127,835) infants born to women with hyperemesis and low weight gain
NVP not related to birth weight of baby. (13) (19) (44) (48) (53) (63) (80) (82) (104)
Total: Ten References
Hyperemesis gravidarum associated with average birth weight babies.
(10) (36) (61) (62) (64) (73) (125) Total: Seven References
Hyperemesis Gravidarum increased incidence of low birth weight babies.
(18) Total: One Reference
Severe Hyperemesis gravidarum associated with low birth weight babies.
(28) t (29) (33) (42) (158) Total: Five References
No NVP associated with low birth weight babies. (5) (11) (21)
Total: Three References
t P value recorded
Please note this guideline is for moderate to severe NVP symptoms rather than HG
RCOG Green-top Guideline No. 69
The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum
BMJ Clinical Update 2018
Management of severe pregnancy sickness and hyperemesis gravidarum
The risk of a baby being born with a congenital abnormality - the difference between relative and absolute risk
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