Hyperemesis Gravidarum And Hydatidiform Mole
24. HYPEREMESIS GRAVIDARUM AND HYDATIDIFORM MOLE
- Hyperemesis gravidarum occurred in 26% of patients who had a complete hydatidiform mole, study population not included. (25)
- 8% of patients, 6 out of 74 with complete hydatidiform mole, presented with hyperemesis gravidarum. (55)
- 6% of women with hydatidiform mole presented with hyperemesis gravidarum. (Papua New Guinea). 37 women with hydatidiform moles. (56)
- 23% of 39 women with hydatidiform mole presented with hyperemesis gravidarum (Guadalajora). (57)
- Three out of 15 patients (20%) with hydatidiform mole presented with weight loss due to hyperemesis. (Barnie-Adshead, 1980, not published).
- Six out of 40 women (15%) with hydatidiform mole presented with nausea and vomiting. (58)
- Frequency of most common symptoms occurring prior to evacuation in patients with molar pregnancies (347 patients, 50=14%) excessive nausea and vomiting. (59)
- Roughly 10% of 196 patients with hydatidiform mole are hospitalised with severe vomiting and weight loss. (60)
- Hyperemesis gravidarum occurs in nil of 69 patients with trophoblastic disease. (26)
Hyperemesis gravidarum is more common in hydatidiform moles than in normal singleton pregnancies. (25) (55) (56) (57) Barnie-Adshead (58) (59) (60)
680 moles in 7 references
Total: Eight References
Hyperemesis gravidarum is no more common in trophoblastic disease. (26)
Total: One Reference
24a. NV AND CHORIOCARCINOMA
“Very raised serum and cerebrospinal fluid levels of human chorionic gonadotrophin occur with choriocarcinoma in the absence of nausea and vomiting, provided there are no gastrointestinal or cerebral metastases”. - Personal communication, Bagshawe, K D 1995.
Please note this guideline is for moderate to severe NVP symptoms rather than HG
RCOG Green-top Guideline No. 69
The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum
BMJ Clinical Update 2018
Management of severe pregnancy sickness and hyperemesis gravidarum
The risk of a baby being born with a congenital abnormality - the difference between relative and absolute risk
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