Hyperemesis Gravidarum And Hydatidiform Mole



  1. Hyperemesis gravidarum occurred in 26% of patients who had a complete hydatidiform mole, study population not included. (25)
  2. 8% of patients, 6 out of 74 with complete hydatidiform mole, presented with hyperemesis gravidarum. (55)
  3. 6% of women with hydatidiform mole presented with hyperemesis gravidarum. (Papua New Guinea). 37 women with hydatidiform moles. (56)
  4. 23% of 39 women with hydatidiform mole presented with hyperemesis gravidarum (Guadalajora). (57)
  5. Three out of 15 patients (20%) with hydatidiform mole presented with weight loss due to hyperemesis. (Barnie-Adshead, 1980, not published).
  6. Six out of 40 women (15%) with hydatidiform mole presented with nausea and vomiting. (58)
  7. Frequency of most common symptoms occurring prior to evacuation in patients with molar pregnancies (347 patients, 50=14%) excessive nausea and vomiting. (59)
  8. Roughly 10% of 196 patients with hydatidiform mole are hospitalised with severe vomiting and weight loss. (60)
  9. Hyperemesis gravidarum occurs in nil of 69 patients with trophoblastic disease. (26)



Hyperemesis gravidarum is more common in hydatidiform moles than in normal singleton pregnancies. (25) (55) (56) (57) Barnie-Adshead (58) (59) (60)

680 moles in 7 references

                                                                                                Total:            Eight References


Hyperemesis gravidarum is no more common in trophoblastic disease. (26)

                                                                                                Total:            One Reference





“Very raised serum and cerebrospinal fluid levels of human chorionic gonadotrophin occur with choriocarcinoma in the absence of nausea and vomiting, provided there are no gastrointestinal or cerebral metastases”. - Personal communication, Bagshawe, K D 1995.


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