The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

It is important to fully understand the differentiation of trophoblast cells which separate production
of hyperglycosylated hCG and normal hCG (see figure). Stem cytotrophoblast cells differentiate to
make extra villous invasive cytotrophoblasts which produce hyperglycosylated hCG. They also
differentiate to make villous cytotrophoblast cells which do not produce hyperglycosylated hCG.
These fuse to form multinucleated syncytiotrophoblast cells with 2 to 50 nuclei. The fusion of
cytotrophoblast cells is controlled and promoted by regular hCG. Cytotrophoblast cells are the
principal cells present at the time of pregnancy implantation. These cells rapidly differentiate to
extra villous invasive cytotrophoblast and villous cytotrophoblast cells which fuse to become
syncytiotrophoblast cells as pregnancy advances. Syncytiotrophoblast cells produce the hormone
regular hCG. Hyperglycosylated hCG is an autocrine factor, it functions separate to regular hCG to
promote invasion of implantation of pregnancy and malignancy in trophoblastic diseases. (1)

 Cells

REFERENCE

1. LAURENCE A COLE
New discoveries on the biology and detection of Human Chorionic Gonadotrophin reproductive biology and endocrinology 2009 7:8 doi 10.1186/1477-7827-7-8

#ReadMyStory

"If it wasn't for the helpline I wouldn't have got the help and the treatment I needed to cope."

70-80%

Nausea & vomiting in pregnancy (NVP) is very common, on average it affects 70-80% of pregnant women to a greater or lesser extent.

85%

85% of pregnant women have two episodes of nausea per day.

30%

30% of pregnant women in paid employment need time off work due to NVP.

Resources

You are not alone

If you think you are suffering from HG please call us for support on: 024 7638 2020

Upcoming events

Latest tweet

Latest tweet

If only staying hydrated was this easy! Many healthcare professionals will use Ketone levels as an indicator of deh… https://t.co/xoZhYI4ECo

09:14 6th December



#ReadMyStory

"HG has been a very isolating experience, when i called the helpline i felt listened to for the first time. It gave me the confidence to go back to my Midwife and ask for further help."



Pregnancy Sickness Support

Volunteer log-in


Pregnancy Sickness Support


Become a volunteer                 Forgot password?