The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

It is important to fully understand the differentiation of trophoblast cells which separate production
of hyperglycosylated hCG and normal hCG (see figure). Stem cytotrophoblast cells differentiate to
make extra villous invasive cytotrophoblasts which produce hyperglycosylated hCG. They also
differentiate to make villous cytotrophoblast cells which do not produce hyperglycosylated hCG.
These fuse to form multinucleated syncytiotrophoblast cells with 2 to 50 nuclei. The fusion of
cytotrophoblast cells is controlled and promoted by regular hCG. Cytotrophoblast cells are the
principal cells present at the time of pregnancy implantation. These cells rapidly differentiate to
extra villous invasive cytotrophoblast and villous cytotrophoblast cells which fuse to become
syncytiotrophoblast cells as pregnancy advances. Syncytiotrophoblast cells produce the hormone
regular hCG. Hyperglycosylated hCG is an autocrine factor, it functions separate to regular hCG to
promote invasion of implantation of pregnancy and malignancy in trophoblastic diseases. (1)

 Cells

REFERENCE

1. LAURENCE A COLE
New discoveries on the biology and detection of Human Chorionic Gonadotrophin reproductive biology and endocrinology 2009 7:8 doi 10.1186/1477-7827-7-8

#ReadMyStory

"The helpline was really comforting, and the volunteer peer supporter was so kind, and gave practical support for my GP appointment.."

Did you know?

Use an holistic approach to assessing women, including perinatal mental health support, and recognise that no one measure, including ketones, can reliably assess severity of HG

Resources

You are not alone

If you think you are suffering from HG please call us for support on: 024 7638 2020

Upcoming events

Latest tweet

Latest tweet

Our helpline is closed until Tuesday 15th October for #ICHG2019. But you are not alone! You can still access suppor… https://t.co/pqYuzKgIOR

06:31 13th October



#ReadMyStory

"I am petrified of becoming pregnant again but at least I know I have the support of Pregnancy Sickness Support"



Pregnancy Sickness Support

Volunteer log-in


Pregnancy Sickness Support


Become a volunteer                 Forgot password?