The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

The Source Of Human Chorionic Gonadotrophin From Within Trophoblast Cells

It is important to fully understand the differentiation of trophoblast cells which separate production
of hyperglycosylated hCG and normal hCG (see figure). Stem cytotrophoblast cells differentiate to
make extra villous invasive cytotrophoblasts which produce hyperglycosylated hCG. They also
differentiate to make villous cytotrophoblast cells which do not produce hyperglycosylated hCG.
These fuse to form multinucleated syncytiotrophoblast cells with 2 to 50 nuclei. The fusion of
cytotrophoblast cells is controlled and promoted by regular hCG. Cytotrophoblast cells are the
principal cells present at the time of pregnancy implantation. These cells rapidly differentiate to
extra villous invasive cytotrophoblast and villous cytotrophoblast cells which fuse to become
syncytiotrophoblast cells as pregnancy advances. Syncytiotrophoblast cells produce the hormone
regular hCG. Hyperglycosylated hCG is an autocrine factor, it functions separate to regular hCG to
promote invasion of implantation of pregnancy and malignancy in trophoblastic diseases. (1)



New discoveries on the biology and detection of Human Chorionic Gonadotrophin reproductive biology and endocrinology 2009 7:8 doi 10.1186/1477-7827-7-8

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