Extra Cellular Matrix Of The Decidua And Prostaglandin E2 Synthesis

Extra Cellular Matrix Of The Decidua And Prostaglandin E2 Synthesis 

Tissue remodelling occurs in trophoblast population (villous, columns interstitial) is associated
with changes in the constituents of the extracellular matrix and in the expression of appropriate
matrix receptors by cells. In most biological systems cells require a substrate of cellular matrix
proteins for anchorage and to derive traction for migration. During the first trimester of pregnancy
the cellular matrix proteins laminin and fibronectin are particularly abundant in the uterus. These
proteins are distributed pericellularly around each individual decidual stroma cell (1).

Trophoblast cells bind the matrix of laminin and fibronectin secreted by decidual stroma cells and this interaction is mediated by a combination of functionally active intigrin molecules (1).

It has now become clear that integrins can function as true receptors which are capable of
transducing signals to the cell interior. A possible downstream effect of integrin mediated signal
transduction in trophoblast cells by matrix proteins is the production of enzymes which facilitate
trophoblast invasion such as a family of metalloproteinases (1). The synthesis of
metalloproteinases (MMPS) is dependent on PGE2 production (1).


Ref 1.    LOKE Y W, KING A, BURROWS T D
Decidua in human implantation
Human Reproduction 1995;10(2):14-21

There was a positive correlation between MMP and PGE2 production. Suspended monocytes treated with soluble SIKVAV (100 nanogram/ml) peptide had a 5 fold increase in PGE2 levels (8.5 ± 0.1ng/ml) as compared with untreated cells (1.6 ± 0.9ng/ml) (2).

Prostaglandin E2 plays an essential role in the metabolism of metalloproteinases which are involved with laminin in the basic structure of the human decidua extracellular matrix (2).

Ref 2. CORCORAN M L, KIBBEY M C, KLEINMAN H K, WAHL L M Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases. Journal of Biological Chemistry 1995;270(18):10365-10368.

70-80%

Nausea & vomiting in pregnancy (NVP) is very common, on average it affects 70-80% of pregnant women to a greater or lesser extent.

85%

85% of pregnant women have two episodes of nausea per day.

30%

30% of pregnant women in paid employment need time off work due to NVP.

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