Differential Localisation Of Prostaglandin E2 Synthase Isoforms In Human Placental Cell Types

Differential Localisation Of Prostaglandin E2 Synthase Isoforms In Human  Placental Cell Types

Increased prostaglandin E2 (PGE2) synthesis involves multiple enzymes and two isoforms of the
terminal enzyme of this biosynthetic pathway PGE synthase (PGES) were recently identified.
Cytosolic PGES (cPEGS) is identical to the Hsp90 chaperone 23 and is reportedly functionally
coupled to constitutive PG endoperoxide H synthase –1 (PGHS-1). Microsomal (mPGES) on the
other hand is inducible by pro-inflammatory cytokines such as IL-!/?$A.*$41-.:60$0-1+'*+$-.*$
cellular localisation of both enzyme isoforms of the human placenta in early gestation (6-10 weeks
from LMP). Cytosolic PGES was immunolocalised to fibroblasts and macrophages in villous
stroma at 6 weeks gestation whereas PGES was localised in extravillous trophoblasts (EVT’s) as
well as macrophages in early gestation (6 weeks) tissues. Microsomal PGES was observed in
cytotrophoblast (CT’s) but not in syncytiotrophoblast (ST’s) in early gestation (6 weeks).
Apoptotic early gestational ST’s were heavily stained with cPGES, previous studies have shown
that mPGES-1 is co-localised with PGHS-2. PGHS-2 has immunolocalised to both extravillous
and syncytiotrophoblasts in early gestation. Microsomal PGES-1 appears to be associated with the
invasive phenotype EVT in basal plate and all columns suggesting PGE2 may play a part in the
invasive process of cytotrophoblast cells, whereas cytosolic PGES would be involved in apoptosis
or repair mechanisms (1).

REFERENCES

1. MEADOWS J W, PITZER B, BROCKMAN D E, MYATT L. 

Differential Localisation of Prostaglandin E Synthase Isoforms in

Human Placental Cell Types.

Placenta 2004;25:259-265.

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