Twins in relation to NVP or HG
33. TWINS IN RELATION TO NVP OR HG
1. Incidence of hyperemesis gravidarum in single pregnancies (90,153 pregnancies) was 3.58 per thousand. Incidence of hyperemesis gravidarum in twin pregnancies (986 twin pregnancies) 14.2 per thousand. A very highly significant relationship (P=0.001) between multiple pregnancy and hyperemesis gravidarum. (10)
2. We certainly have a high incidence of hyperemesis gravidarum among our patients with twin pregnancies, 25.9 per thousand for twins compared to 5.1 per thousand for singletons. (15,099 single pregnancies and 193 twin pregnancies in the study). (26)
3. 2.2 x risk of hyperemesis gravidarum in twins (P=
4. Hyperemesis gravidarum was statistically more common in twin pregnancies. (86 twin pregnancies in the study). (P
5. In multiple gestations (83 twin and one triplet pregnancies) 73 (86.9%) suffered from nausea and vomiting. This difference between single, as opposed to multiple gestation, is statistically significant (P=
6. Higher frequency of NVP seen in study for twin pregnancies. Eight twins, seven (87.5%) had NVP. 71% NVP in study population. (6)
7. Of the blacks studied, 24 had twins. 18 (75%) of them maintained that they were very sick in that pregnancy. (41)
8. Twinning rate was increased when the woman had used meclozine. 16,536 women used meclozine in the first 12 weeks of pregnancy. Meclozine was mainly used for NVP. (133)
Increased incidence of hyperemesis gravidarum in twin pregnancies.
t(10) t (18) t (26) (29) t
Total: Four References
1498 twin pregnancies in 8 references
Increased incidence of NVP with twin pregnancies.
(5) (6) (41) (133)
Total: Four References
t P value recorded
* Being a twin does not make one more liable to NVP. Information from 2,655 twin pairs who have each had a pregnancy. (47)
Did you know?
Evidence is mounting from biological research that GDF15, the key driver of cancer cachexia, is linked to severe NVP
Please note this guideline is for moderate to severe NVP symptoms rather than HG
RCOG Green-top Guideline No. 69
The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum
BMJ Clinical Update 2018
Management of severe pregnancy sickness and hyperemesis gravidarum
The risk of a baby being born with a congenital abnormality - the difference between relative and absolute risk
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