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3a. INCIDENCE OF VOMITING IN EARLY PREGNANCY

 

1.

Vomiting occurred in 162 of 500 patients: 32.4%

Vellacott (27)

2.

Vomiting occurred in 190 of 363 women: 52.3%

Gadsby (50)

3.

Vomiting in 234 out of 414 women: 56.5%

Tierson (21)

4.

104 women in study: 50% vomited

Jarnfelt-Samsioe (19)

5.

9,098 women in study: 4,472 vomited: 55%

Klebanoff (18)

6.

903 women in study: 46% vomited

Weigel (44)

7.

1,453 women in study: 63.5% vomited

R Chin (63)

8.

129 women in study: 40.3% vomited

Crystal (77)

9.

160 women in study: 60 (37.5%) reported vomiting,

50.8% of those who had nausea vomited

Lacroix (80)

10.

193 women in study: 22.3% vomited

Emelianova (83)

11.

825 women in study: 47.3% vomited

Weigel (31)

12.

1,513 women: 46% vomited

Meyer (45)

13.

3,675 women: 1406 vomited (38.3%)

Kallen (132)

14.

Group time 1n = 306 gestational age approx. 9 weeks and group time 2n = 231 gestational age 60% of women did not vomit.

Swallow (156)

 

Total women in 13 references 19,330. Total who vomited 9,095.

Range 22.3% - 63.5% vomited. On average 47.1% of pregnant women vomited.

 

3b. SEVERITY OF VOMITING

 

Vomiting Occurring Daily

 

1.

Vomiting occurred daily in 99 out of 500 women: 18.4%.A further 62 women vomited at least once per week.42.3% of those women with nausea vomited.

Vellacott (27)

2.

33% suffered from moderate nausea with occasional vomiting, and in 17% nausea was severe with daily vomiting. 62 women in study.

Jarnfelt-Samsioe (19)

3.

Daily vomiting in 1,000 women: 20.8%.52% of women vomited.

Whitehead (40)

4.

Among 3,675 women who completed NVP questionnaires, 1406 (38.3%) vomited, 938 (25.6%) reported occasional vomiting and 468 (12.7%) daily vomiting.

Kallen (132)

 

Summary

 

Total number of women in 4 studies 5127.

Total number of women who vomited daily 777.

Percentage of women who vomited daily in 4 studies 15.1%.

3c. TOTAL NUMBER OF VOMITS IN EACH WOMAN

 

1.

Total of 10 or less vomits in 92 out of 363 women: 25%

Gadsby (50)

2.

Total of 40 or more vomits in 36 out of 363 women: 9.9%

Gadsby (50)

3.

Max number of vomits in one woman’s pregnancy: 258

Gadsby (50)

4.

160 women in study, vomiting occurred an average of 9.8 times per pregnancy.

Lacroix (80)

5.

Vomiting occurred on a mean of 5.6 days for the 60 women who vomited. 160 women in study.

Lacroix (80)

 

Summary

 

Women who vomit in pregnancy 25% have less 10 vomits per pregnancy, about 10% have more than 40 vomits per pregnancy.

 

 

3d. SIGNIFICANCE OF VOMITING IN RELATION TO NAUSEA

A POSITIVE CORRELATION

 

1. Women experiencing severe vomiting i.e. 40 or more vomits per pregnancy, had significantly more hours of nausea than those with less severe vomiting, i.e. 10 or less vomits per pregnancy. The mean hours of nausea for those with severe vomiting was 136 hours, compared to those with less severe vomiting 41 hours.
Mann Whitney U test PTherefore, measuring severe nausea is equivalent to measuring severe vomiting. 363 women in study. (50)

 

2. Significant correlation between severity of reported nausea and vomiting (r 0.53 P

 

3. 33% suffered from moderate nausea with occasional vomiting and in 17% nausea was severe with daily vomiting. 62 women in study. (19)

 

Summary

 

Significant correlation between severity of nausea and severity of vomiting in pregnancy.

Pooled population in 3 studies 554.

 

3e. NUMBER OF WOMEN WHO VOMIT WITHOUT ANY NAUSEA

 

1. All women who reported vomiting reported nausea as well. 1,000 women in study. (40)

2. No-one had vomiting only. 363 women in study. (50)

3. 12 women (2.8%) had vomiting but did not have accompanying nausea. 414 women in study. (21)

 

Percentage of pregnant women with vomiting only (no nausea) 0.64%

 Pooled population in 3 studies 1777.